According to a new study presented at the American Physiological Society (APS) conference in Estes Park, Colorado, blocking the action of a certain hormone in human immune cells can reduce the risk of heart disease.
Researchers, as explained in the press release, in fact, found that blocking mineralocorticoid (MR) receptors, a protein involved in maintaining salt and water levels in the body and present in immune cells, can reduce the risk of pathologies such as heart attacks and strokes.
Higher levels of aldosterone, a hormone that regulates water balance, are actually associated with an increased risk of these diseases. This hormone is directly related to the mineralocorticoid receptor as it can activate or deactivate it. With age, the level of this receptor increases, which contributes to the growth of heart disease.
Researchers have experimented on mice and found that rats without MRI are characterized by lower levels of vascular inflammation and fewer plaques (fatty substances that accumulate on the walls of the arteries).
According to the researchers, these results indicate that “a reduction in plaque inflammation due to MRI blockage can improve clinical outcomes with MRI antagonists.
Therefore, mineral corticoid receptors can be an excellent therapeutic target for treating atherosclerotic diseases, heart attacks and strokes, says one of the authors of the study, Joshua Man, a researcher at Tufts Medical Center in Boston.
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